Research and development

This section introduces the research and development of our company.

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Overview of research and development

According to recent study results of gaseous molecules, various physiologic activities have been seen of gaseous molecules of nitric oxide, carbon monoxide, hydrogen sulfide and hydrogen within a living body. Ever since Osawa et al. reported in Nature Medicine (Ohsawa I, Ishikawa M, Takahashi K, et al : Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals. Nat Med, 2007, 13: 688-694) that hydrogen gas eliminates the hydroxyl radical with the strongest oxidizing power even in reactive oxygen species, research on molecular hydrogen has expanded exponentially.
 It is understood from recent study results that molecular hydrogen demonstrates not only an antioxidant effect, but also an anti-inflammatory effect, an antiallergic action, an anti-apoptotic action, a lipid hypermetabolic action, etc., and approximately 380 original theses on animal tests and clinical studies of the effects of molecular hydrogen have been reported until now.
 MiZ has foreseen the possibilities of medical use of molecular hydrogen for the past twenty years, drawn a conclusion that molecular hydrogen will provide a paradigm shift in medicine of the 21st Century, and researched and developed based on a main theme of pursuing ideal technology regarding a hydrogen administration method for clinical application to humans.
 Technologies regarding hydrogen administering methods developed by MiZ until now are (1) method of administering dissolved hydrogen orally, (2) method of adding hydrogen to a liquid drug and administering it by injection, intravenous drip, or the like, and (3) method of administering hydrogen gas as an exhaust gas. We believe that these technologies can inevitably contribute to medicine of the 21st Century.

Primary patents

  1. Title of the Invention ‘ELECTROLYTIC CELL AND ELECTROLYZED WATER GENERATING APPARATUS’ (JP 3349710)
  2. Title of the Invention ‘METHOD AND APPARATUS FOR GENERATING A HYDROGEN-RICH SOLUTION FOR A LIVING BODY’ (JP 4486157)
  3. Title of the Invention ‘ANTIOXIDANT METHODS, ANTIOXIDANT AND FUNCTIONAL WATER, AND IT’S USE’ (JP 4511361)
  4. Title of the Invention ‘SELECTIVE HYDROGENATION APPARATUS FOR SOLUTION FOR A LIVING BODY’ (JP 4652479)
  5. Title of the Invention ‘HYDROGENATION APPARATUS FOR SOLUTION FOR A LIVING BODY’ (JP 4744641)
  6. Title of the Invention ‘SELECTIVE HYDROGENATION APPARATUS FOR SOLUTION FOR A LIVING BODY’ (JP 4756102)
  7. Title of the Invention ‘NONDESTRUCTIVE APPARATUS FOR GENERATING HIGHLY CONCENTRATED HYDROGEN SOLUTION’ (JP 4769903)
  8. Title of the Invention ‘SELECTIVE HYDROGENATION APPARATUS FOR SOLUTION FOR A LIVING BODY’ (JP 4950352)
  9. Title of the Invention ‘NONDESTRUCTIVE APPARATUS FOR GENERATING HIGHLY CONCENTRATED HYDROGEN SOLUTION’ (JP 5038546)
  10. Title of the Invention ‘HYDROGEN GAS SUPPLY APPARATUS FOR LIVING BODY’ (JP 5091364)

(Number of patent applications/ registered patents: 133; domestic: 27, foreign: 40)